Cefixime is a semisynthetic third generation antibiotic from the group of cephalosporins , which has a bactericidal effect. Cefixime is the main active substance of a number of drugs, produced in the form of tablets, capsules, powder for the preparation of oral suspensions.
The use of cefixime and its analogues
Cefixime is a broad-spectrum antibiotic that is effective against most of the gram-positive and gram-negative microorganisms. The drug is ineffective against pseudomonads, Staphylococcus aureus and most of the enterococcal infections. Preparations based on cefixime are used to treat:
- acute conditions and exacerbation of chronic bronchitis, pharyngitis, tonsillitis, bacterial sinusitis;
- inflammation of the lungs, middle ear;
- intestinal infections;
- uncomplicated urinary tract infections;
- uncomplicated gonorrhea.
Contraindications to the use of the drug are individual intolerance and porphyria. It is used with caution in chronic renal failure, pseudomembranous colitis and in old age.
The average daily dose of ceficimax for an adult is 400 mg.
During the administration of the drug on the basis of cefixime, side effects can occur in the form of:
- dizziness;
- headache;
- nausea;
- diarrhea;
- flatulence;
- urticaria and skin rashes.
Synonyms for cefixime
Synonyms in medicine are usually called drugs with the same active substance, which differ only in the name and some auxiliary substances.
Cefixime in tablets exists in a dosage of 400, 200 and 100 mg. The following tablets contain 400 mg of cefixime:
- Loprax;
- Maxibat;
- Sorcef;
- Supraks Comfortab;
- Supraks Solutab;
- Ceforal Solutab.
Drugs that are released in a dosage of 100 and 200 mg:
- Cefic;
- Cefigo;
- Flamixi;
- Fix.
Other forms of production of cefiximex:
- Cefix in the form of powder for the preparation of suspension and in capsules;
- Flamix (capsules);
- Sorcef (granules for the preparation of a suspension);
- Loprax (powder for suspension);
- Maxibat (powder for the preparation of suspensions).
Analogues of cefixime
The closest analogues of cefixin are the other antibiotics of the cephalosporin group. They have the same effect and are applied when the active substance (cefixime) or the formulation form is not suitable for the patient.
The latter is especially important, since cefixime in the form of a solution for injection is not released, so if necessary intravenous or intramuscular injections use analogs.
In solutions for injections, preparations are used primarily on the basis of ceftriaxone:
- Auroxon;
- Bliicef;
- The Partseef;
- Zefort;
- Emsef.
There are also medicines based on cefipim:
- Quartzsef;
- Maksipim;
- Maksitsef;
- Norfepim;
- Cefipim.
Preparations based on cefazolin:
- Reflin;
- Cesolin;
- Cefazolin.
Means on the basis of cefoperazone:
- Cibanex;
- Cerason.
Dosages can be from 250 to 2000 mg of active ingredient in one bottle.
In tablets and granules, analogues of cefixime may be considered:
- Cephalexin;
- Zinnat;
- Tzedek.
These drugs belong to the same group, but are first and second generation antibiotics, have a narrower spectrum of action and may be less effective.
In some cases, under the prescription of a doctor, cephalosporins can be replaced with antibiotics of the penicillin group.
It should be noted that with individual intolerance to cefixime, other antibiotics of this group and similar groups (penicillins) are usually intolerant. In this case, another broad-spectrum antibiotic will be chosen for treatment.