AMG-hormone (antimulylerovskiy hormone) or, as it is also called - Muller's inhibitory substance, is responsible for differentiation of the sex of the embryo, it is involved in the maturation of the follicle and in spermatogenesis. This indicator is often used to determine the causes of female and male infertility , as well as in the diagnosis of certain tumors.
AMG is the norm in women
From birth to menopause in women, this hormone is produced by granular cells of the ovaries, and its highest levels are observed in tumor cells. AMG in women is defined in order to identify delayed or premature puberty, to establish the sex, when this question is called into question, in the diagnosis of granulosa cell carcinoma of the ovaries and in some other cases.
In addition, antimulylerov hormone recommended to take in preparation for IVF. This analysis is carried out on certain days of the cycle, while the ratio of inhibitor B to the level of AMN is evaluated. For IVF, the level of AMG-hormone should normally be at least 0.8 ng / ml.
In general, at the reproductive age, the concentration of AMG in women normally remains 2.1-7.3 ng / ml. If the level of the hormone decreases to 1.1 ng / ml and lower, it is a question of reducing the functional reserve of the ovaries. And with a sharp decline in this reserve, the rates are reduced to 0.8 ng / ml and lower.
Low AMG and IVF
Such a decrease in the basal level of AMG suggests a low probability of pregnancy during IVF. Patients who have a reduced functional reserve of the ovaries and an anti-Muller hormone level react worse to the stimulation that is carried out at the first stages of the in vitro fertilization program.
In addition, the level of AMG in IVF is checked in order to assess the risk of such excessive stimulation. Sometimes this procedure leads to a life-threatening condition - a syndrome of ovarian hyperstimulation. Given this knowledge, you can further plan a program of infertility treatment.
How to prepare for the analysis?
Going on the delivery of AMG analysis you need to follow some recommendations:
- do not eat 12 hours before the procedure;
- It is necessary to completely exclude the intake of androgens within 48 hours before delivery of blood;
- do not smoke at least half an hour before the analysis;
- it is recommended to conduct the analysis on the 3rd or 4th day of the menstrual cycle.
For the analysis, the woman takes venous blood, and the method of investigation in this case is an enzyme immunoassay. The units of measurement are nanograms per milliliter (the concentration of the substance in the blood is measured).