Amyloidosis - symptoms

Amyloidosis is characterized by the accumulation of an abnormal protein in the body. At the same time in the normal state it is not in the body at all. Amyloidosis has symptoms, by which it is possible to determine the degree and complexity of the disease.

Amyloidosis of internal organs

When the disease develops, an abnormal protein accumulates, which causes the formation of autoantibodies. After the interaction of the antigen with the antibody, the protein forming the amyloid precipitates. In the future, he can displace elements of the organ, which leads to his complete death. The disease can affect all important internal organs, for example, the heart or intestines.

Symptoms of amyloidosis of the intestine:

• discomfort and heaviness in the abdomen;
• blunt and spasmodic pain;
• constipation or diarrhea;
• anemia of the blood;
• leukocytosis;
• hyperglobulinemia;
• hypoprothrombinemia;
• hypocalcemia.

Amyloidosis of the heart disrupts the elasticity of tissues, and also complicates heart contractions and heart rhythm. The organ becomes unable to pump the necessary amounts of blood and normally maintain the blood supply to the human body. The main symptoms of this disease are:

• shortness of breath ;
• swelling;
• weakness;
• nausea;
• arrhythmia.

Amyloid can also affect nerves. Manifestations of amyloidosis of the peripheral nerve are the following:

• tingling and weakness in the muscles;
• disturbance of balance;
• dizziness while standing;
• violation of control of urination and defecation;
• itching at the fingertips.

Amyloidosis of the skin

There are several forms of skin lesions:

• primary local amyloidosis of the skin;
• secondary local amyloidosis of the skin;
• local amyloidosis of the skin with total amyloidosis.

With this disease, numerous, dense, slightly shiny nodules appear on the skin, which constantly itch. They are small in size and pinkish and tawny in color. Sometimes nodules can have horny layers and scales on the surface. Often, in appearance, they resemble red lichen planus, and with its large distribution - foci of neurodermatitis.

With secondary amyloidosis discs appear that are dense to the touch and have a dark pink hue. Most often, it manifests itself in people who are sick with tuberculosis, malaria, skin lesions with abscesses.

Local amyloidosis can manifest as small papules, for example, on the lower leg, less often on other parts of the body. They have the appearance of dense hemispherical strips or conical papules that are closely located next to each other. There is a characteristic itching.