Diroton is a pill that reduces the formation of angiotesin II from angiotensin I, thereby reducing the degradation of bradykinin and increasing the synthesis of prostaglandins. This effect of the drug on the body contributes to the reduction in OPSS, AD, preload and pressure in the pulmonary capillaries. In addition, the drug can cause an increase in the minute volume of blood and expand the arteries.
Diroton, like its counterparts, can prolong the life of patients with heart failure in chronic form and slow the development of left ventricular dysfunction in patients after a previous myocardial infarction.
The active ingredient in the composition of Diroton is lisinopril. There are a lot of analogues of the drug with respect to the active substance. Question: "What can replace Diroton?" Usually occurs when the patient has contraindications to taking the drug, so we'll talk about his most popular substitutes.
What is better - Lizinopril or Diroton?
Lizinopril and Diroton have many similarities. They are issued in the same form - tablets of 5 mg, 10 mg and 20 mg, and are taken, once a day, regardless of food intake. But only Diroton needs to use twice as much - 10 mg once a day, and only 5 mg of lisinopril. In both cases, the full effect is achieved in the second or fourth week.
The main differences are in contraindications, since Diroton is forbidden to take patients with hereditary edema of Quincke, and lisinopril to patients not carrying lactose, with lactose deficiency, and also having glucose-galactose malabsorption. In the rest, the contraindications for taking medications are absolutely the same:
- pregnancy;
- lactation period;
- angioedema in history;
- hypersensitivity to the drug.
Which is better - Diroton or Enalapril?
The active substance in Enalapril is enalapril - this is the main difference between drugs. In this case, the drug has a narrow spectrum of effects, unlike Diroton, it is used only for two diseases:
- arterial hypertension;
- chronic heart failure.
It can not be categorically forbidden to use for kidney failure, after kidney transplantation and primary hyperaldosteronism. The remaining contraindications are identical to Diroton.
Which is better - Lopaz or Diroton?
Diroton and Lozap also differ in the active substance, since in the second case it is Lozartan. Because of what the drug is also used to treat not all heart diseases, but only with arterial hypertension and heart failure. The contraindications of the drugs are identical. Therefore, Diroton is replaced by Lozap only in cases where the patient is hypersensitive to lisinopril.
Summarizing, we can say that each drug has its own advantages. Analogues of Diroton are contraindicated or active substance, which often becomes a decisive factor in the choice of medication.