Doxycycline is a semisynthetic antibiotic with a wide spectrum of action, belonging to the group of tetracyclines. It is produced by different manufacturers in various dosage forms:
- capsules;
- pills;
- suspension;
- powder for solution.
Pharmacological action of antibiotic Doxycycline
The antibiotic in question acts by inhibiting the synthesis of proteins in the cells of the pathogens of the infection, as a result of which the microbes lose their activity and the ability to reproduce. It is active against the following microorganisms:
- aerobic gram-positive bacteria (staphylococci, streptococci, anthrax, listeria);
- aerobic gram-negative bacteria (gonococci, Escherichia coli, Shigella, Salmonella, enterobacteria, Klebsiella, pertussis sticks);
- anaerobic bacteria (clostridia);
- chlamydia, mycoplasma, rickettsia, pale treponema.
Microorganisms showing resistance to doxycycline:
- Pseudomonas aeruginosa;
- bacteroides;
- Proteins;
- serrations.
Getting into the body, the antibiotic is widely distributed in tissues and liquid media. Therapeutic doses of the drug are detected in the liver, lungs, bones, spleen, exudate of the paranasal sinuses, bile, eye tissues after half an hour after the administration. In spinal fluid penetrates in a small dose. It is excreted from the body with an antibiotic with feces and urine.
Indications for the appointment of Doxycycline:
- infection of ENT organs and respiratory tract;
- gastrointestinal infections;
- cutaneous infectious lesions;
- infectious and inflammatory diseases of the genitourinary system;
- some venereal diseases;
- osteomyelitis;
- Tularemia;
- Lyme disease ;
- typhus and others.
What can replace Doxycycline?
In principle, analogs of Doxycycline are practically all antibiotics of the tetracycline series - preparations based on:
- tetracycline;
- metacycline hydrochloride;
- minocycline;
- glycocycline and others.
These drugs are characterized by a similar mechanism of antimicrobial action and almost similar pharmacological properties. There are only a few differences associated with the characteristics of absorption and metabolism.
Doxycycline is a substance derived from the antibiotic of a natural tetracycline antibiotic, which is produced by a special kind of fungus. At the same time, for efficiency and safety for the body, doxycycline far exceeds its "progenitor". Thanks to the chemical synthesis, a high degree of purification of the antibiotic is achieved, as a result of which it is better absorbed and is capable of causing a minimum of side effects. Doxycycline less than other tetracycline antibiotics suppresses beneficial intestinal flora, is characterized by more complete absorption and longer duration of action. Therefore, its use is more preferable.
In addition, Doxycycline is available in several forms:
- doxycycline hydrochloride;
- doxycycline giklat;
- doxycycline monohydrate.
At us the most widespread is the first form presented on the pharmacological market by such preparations, as:
- Vibramycin;
- Doksybeene;
- Bassado;
- Doxycycline Nycomed and others.
But, unfortunately, dioxycycline hydrochloride when taken orally in case of a delay in the esophagus (for example, because of anatomical
A modern analogue of drugs based on doxycycline - Unidox Solutab. This drug contains doxycycline monohydrate, which when dissolved does not cause an increase in acidity and is absorbed in the gastrointestinal tract almost completely. At the same time, mucous membranes do not suffer, there is no significant effect on the intestinal microflora, and the probability of development of dyspeptic phenomena is minimal. The agent can be dissolved in water, obtaining a suspension, which excludes the possibility of its delay in the esophagus.