Of course, it is quite difficult to cope with bouts of real migraines, but it's quite possible to ease the pain. Not so long ago, a relatively new drug, Excedrine, that helps migraine, has been removed, it relieves spasms, pains and brings the desired relief.
Composition of the Medication for Migraine Excerdin
The new remedy for migraine Excerdin does not contain any special components that easily cope with bouts of pain. Its components are so famous and simple that most people wonder how they act. But it is because these substances are together that they bring the desired result. The composition of the tablets from migraine Excedron includes:
- paracetamol 250 mg;
- acetylsalicylic acid - 250 mg;
- caffeine - 65 mg.
The paracetamol, contained in the preparation from migraine, has antipyretic and analgesic effect due to its influence on the thermoregulatory center in the hypothalamus and the ability to inhibit the synthesis of prostaglandins in peripheral tissues.
Acetylsalicylic acid is also able to reduce the pain caused by the inflammatory process. It also dilutes blood and promotes microcirculation in the hearth of inflammation itself.
Caffeine dilates the blood vessels, increases the reflex excitability of the spinal cord. Due to its content in the remedy for migraine, Excedrine increases blood flow in the brain and its vessels are in normal tone.
Recommendations and contraindications
The instructions to the drug says that you can apply it with the following problems:
- headache;
- migraine;
- neuralgia;
- toothache ;
- pain in muscles and joints;
- pain during menstruation.
It should be remembered that the medicine for migraine Excerdin has a number of contraindications, in which it is not recommended to use:
- erosive and ulcerative problems with the gastrointestinal tract;
- gastrointestinal bleeding;
- aspirin asthma;
- hemorrhagic diathesis;
- hemophilia;
- hypoprothrombinemia;
- avitaminosis K;
- kidney failure;
- pregnancy;
- the period of breastfeeding;
- arterial hypertension;
- severe course of ischemic heart disease;
- glaucoma;
- sleep disturbance;
- increased excitability;
- surgical intervention, which is accompanied by bleeding.
This drug is not recommended for children under 15 years and those who have liver problems, and also suffer from gout. Children can develop Reye's syndrome, which will manifest itself in the form of hyperpyrexia, metabolic acidosis, impaired functions of the nervous system and liver.
When an overdose of this drug or an increased sensitivity of the body to some components can lead to the occurrence of side effects. They can appear as:
- nausea;
- vomiting;
- tachycardia ;
- dizziness;
- reduced visual acuity, as well as hearing;
- high blood pressure.
Interaction with other drugs
It is worth saying that Excerdin against migraine is able to enhance the effect of other components:
- indirect anticoagulants;
- heparin;
- reserpine;
- steroid hormones;
- hypoglycemic drugs.
It is important to note that concomitant administration with other NSAIDs or methotrexate can trigger the occurrence of side effects. The use of paracetamol and ethanol leads to hepatotoxic effects. Simultaneous reception of barbiturates, rifampicin, salicylamide and antiepileptic drugs can provoke the appearance of toxic metabolites that affect the liver. But spironolactone, furosemide, hypotensive and anti-hypertensive drugs become less effective when interacting with this drug.