Amoxiclav is a combined antibacterial drug that consists of amoxicillin trihydrate and clavulanic acid in a ratio of 4: 1 (only in the suspension ratio is often 7: 1).
Amoxicillin trihydrate is a broad-spectrum antibiotic , and clavulanic acid is an inhibitor of enzymes that produces a microorganism, so that amoxicillin does not destroy them. The drug is well absorbed through the intestinal tract, spreads blood to all organs and is excreted unchanged by the kidneys, does not penetrate the blood-brain barrier, but penetrates the placental barrier.
Indications and contraindications to the drug
As for other antibiotics, the main indications for Amoxiclav are the inflammatory processes of different localization. The drug is spiked when:
- acute and chronic inflammatory processes of the upper respiratory tract;
- acute and chronic inflammation of the skin and soft tissues;
- acute and chronic diseases of the bronchi and lungs;
- kidney and bladder problems;
- infections of bone and connective tissue;
- odontogenic (associated with the teeth) inflammatory processes;
- infections of the gastrointestinal tract;
- for the prevention and treatment of postoperative complications;
- inflammatory processes in gynecology.
Contraindications for Amoxiclav:
- hypersensitivity to the drug or its components;
- increased sensitivity to antibiotics penicillin, cephalosporin series;
- lymphocytic leukemia and infectious mononucleosis;
- liver disorders caused by the drug in the anamnesis (cholestatic jaundice, hepatitis).
Amoxiclav during pregnancy - instruction
The developers of the drug claim that they conducted studies on pregnant women who took Amoxiclav during pregnancy, and even in the first trimester (the first 12 weeks) and no side effects on the fetus were found. And the drug itself is not contraindicated in pregnancy, and the reviews of those who drank Amoxiclav during pregnancy are positive.
But the fact is that one of the components of the drug is the antibiotic amoxicillin, from the group of semisynthetic penicillins, and they penetrate the placental barrier. About teratogenic (mutagenic, contributing to the development of fetal malformations ), the action of antibiotics of this series of opinions is still ambiguous, but it is better to avoid the use of the drug in the first 5-7 weeks of pregnancy. And in the second and third trimester, amoxicillin has been shown to be safe for the fetus and is often prescribed for the treatment of various kinds of infections.
But according to the second component of the drug there is little information, and therefore the drug is often replaced by less persistent forms of amoxicillin release. But Amoxiclav, more resistant to microorganisms, has fewer side effects and is more effective thanks to clavulanic acid, so only a doctor can select and change the drug to treat the infection.
Amoxiclav during pregnancy - dosage
The dosage of the drug in pregnant women does not differ from the usual one and depends only on the severity of the disease. Since the amount of clavulanic acid in Amoxiclav tablets is the same (125 mg), only the dose of amoxicillin is calculated. With light and medium
Depending on the daily dose and the form of release of the drug, you can calculate how many and what tablets you need to take pregnant. For example, Amoxiclav 1000 in pregnancy is used for 1 tablet in the morning and in the evening, if the dosage of the drug is -1000 mg 2 rza per day, the drug Amoxiclav 625 in this case, you need to drink 2 tablets (4 tablets per day), which is not entirely convenient. The drug Amoxiclav 625 in pregnancy is used when the dosage of the drug is 500 mg every 8 hours. It is taken 1 tablet every 8 hours, or use ½ tablets with a dosage of 1000 mg. The drug is better to take, dissolving in 100 ml of water before meals, the course of treatment - 5-7 days.