The drug cefazolin is a semi-synthetic cephalosporin antibiotic, which is used parenterally. This drug has an antimicrobial effect, which is aimed at destroying the process of connecting and disconnecting the cell membranes of microorganisms.
By its composition, the drug is the least toxic among the remaining antibiotics. Actively acts on the following pathogenic microorganisms: various types of staphylococci, streptococci and E. coli. ENT-doctors very often prescribe to their patients cefazolin with angina.
The use of cefazolin
- with microbial infections of the nasal cavity, paranasal sinuses, pharynx, larynx, trachea and bronchi, tonsillitis (angina) and ENT organs (inflammation of the ear and otitis media);
- diseases of the pelvic organs, urinary and bile excretory systems;
- inflammation of the skin;
- peritonitis;
- inflammatory processes of the skeleton;
- mastitis;
- sepsis;
- endocarditis;
- with thermal and mechanical damage to the skin;
- with syphilis;
- as prevention of infections before and after operations.
Form release - powder for the preparation of solution for injection. Cefazolin in tablets is not available.
Injection of cefazolin
With the help of injections it is injected into the body intravenously or intramuscularly. Be sure to know about how to properly dilute cefazolin. In order to make intravenous injections, the drug is diluted with saline solution of 4-5 ml. For intravenous injection, dilute cefazolinum 1 ampoule in the proportions of 10 ml of saline, enter into the vein slowly in 3-5 minutes. For intramuscular injections, cefazolin should be diluted with novocaine.
The dosage of cefazolin with novocaine is in the proportion of 250 ml or 500 ml of cefazolin based on 2 ml of novocaine. Novocaine should not be more than 0.5% concentration. If you notice that the medicine does not dissolve properly to the end, you need to warm the ampoule in your hand so that the medicine reaches the temperature of the body and then mix the medicine well. Unused cefazolin in an open form can be stored in the refrigerator for 24 hours.
Cefazolin - side effects
The high likelihood of allergy in the process of treatment with this drug in the form of rashes on the skin, itchy hyperthermia, eosinophilia, bronchospasm, angioedema, arthralgia, anaphalactic shock, multiforme exudative erythema. From the side of the circulatory system, there may be problems in the form of leukopenia, a decrease in the number of platelets, neutropenia, thrombocytosis, hemolytic anemia. There were also rare cases of transient increase in the level of aminotransferase of the liver. If the patient has problems with the kidneys, nephrotoxicity may occur. Nausea, vomiting, signs of inflammation of the mucous membrane of the colon, etc. can also occur. With prolonged treatment, dysbacteriosis or superinfections may occur. Injections that are administered intramuscularly can be painful. When injected intravenously, phlebitis may occur. This drug can not be used for children under 8 years old, since they are contraindicated in novocaine.
Analogues of cefazolin:
- cocus;
- reflin;
- totatef;
- cesium;
- cefamezin.
Remember that before you replace one medicine with another, you should always consult your doctor. In order to prevent problems of the gastrointestinal tract and dysbacteriosis it is recommended to take in parallel with the cefazolin preparation a linex, bifiform or other preparations containing lactobacilli.