Today, a variety of preparations are being prepared for the treatment of various diseases, with the addition of bee venom, a valuable medicinal raw material, which was effectively used even in ancient Egypt, India and China. Earlier treatment with bee venom was carried out by stinging, but today it is possible to conduct therapy in a more acceptable way - by rubbing, injecting, etc. One of the known preparations on the basis of bee venom is the apizartron ointment, the purpose, the method of application and contraindications of which we will talk later.
Composition and properties of ointment Apizartron
Ointment Apizartron, in addition to bee venom, also contains active ingredients such as methyl salicylate and allyl isothiocyanate (allyl isothiocyanate). Auxiliary substances in the composition of the drug are:
- alcohol cetearyl emulsified;
- sodium lauryl sulfate;
- petrolatum;
- water prepared.
The main component of Apizarthron, bee venom , is a combination of a large number of biologically active substances that, upon ingestion, cause a series of reactions, supplement and strengthen each other's action. The most important substances of bee venom are:
- histamine;
- melithine;
- apamin;
- guaruronidase;
- phospholipase.
Bee venom has the following therapeutic effect:
- analgesic;
- anti-inflammatory;
- antiexudative;
- desensitizing;
- antibacterial.
These effects are achieved by increasing blood circulation, increasing the permeability of capillaries, activating the synthesis of corticosteroids by the body and releasing histamine and cortisone, as well as blocking the synthesis of prostaglandins.
Methylsalicylate is a non-steroidal anti-inflammatory agent that easily penetrates deep into tissues, providing analgesic effect, normalizing permeability of capillaries, and also reducing edema and infiltration. In addition, methyl salicylate in the composition of the ointment ensures rapid penetration into the inflammatory focus of bee venom and the third active ingredient, allyl isothiocyanate.
Allyl isothiocyanate, having local irritating and thermal properties, causes an increase in local blood flow and oxygen intake, activation of metabolic processes, acceleration of the removal of toxic metabolic products from the pathological focus.
Indications for the use of ointment Apizartron:
- diseases of the musculoskeletal system (osteoarthritis, rheumatic soft tissue damage);
- joint pain (including those associated with rheumatic joint damage);
- muscular pain of various origin;
- Neuralgia (neuritis, sciatica , lumbago, etc.);
- violations of peripheral circulation;
- pain as a result of soft damage to muscles, ligaments, tendons, and bruises and sprains;
- as a heating aid before and during sports activities.
Method of application of ointment Apizartron
According to the instructions, ointment Apizarthron should be applied 3-4 times a day as follows:
- Apply to the lesion site and spread a thin layer.
- After 1-3 minutes, after the appearance of local visible reactions (reddening of the skin, sensation of heat), slowly and intensively rub in the skin with massage movements.
- Treated the place warmed.
The course of treatment, as a rule, is 7-10 days in case of acute processes; with chronic diseases, the duration of treatment is increased.
Contraindications to the use of ointment Apizartron:
- severe form of chronic renal failure;
- serious liver disease;
- oncological diseases;
- cutaneous lesions;
- oppression of bone marrow hematopoiesis;
- mental illness;
- acute arthritis;
- intolerance of the drug components.
Analogues of ointment Apizartron
The known analogues of the ointment Apizarthron for the main active ingredient are such preparations as:
- Ungapiven;
- Apiary;
- Virapine.