Warfarin analogues

Warfarin is the oldest drug from the group of anticoagulants , with an overdose being a poison and requiring constant monitoring of blood indicators. To date, there are modern analogues of Warfarin with fewer side effects, among which the most interesting are those that can be taken without regular monitoring of INR (an indicator characterizing the coagulability of the blood).

Modern Warfarin Analogues

Warfarex

Tablets containing 1.3 or 5 mg of active ingredient (sodium warfarin). Are applied at:

• thromboembolism of the lungs;
• deep vein thrombosis;
• heart attack;
• prosthetics of heart valves.

Marewan

Tablets containing 3 mg of sodium warfarin. Are applied at:

• thrombosis;
• infarction and for the prevention of complications after a heart attack;
• other heart diseases, including valve prosthetics;
• treatment and prevention of strokes and ischemic attacks.

Both drugs, in fact, are the same Warfarin and differ only in the content of auxiliary substances. Monitoring INR and other precautions when using them are mandatory.

What else can replace Warfarin?

Here we will consider preparations with other active substances and the type of action that are anticoagulants, and therefore can be used in place of Warfarin.

Pradaxa

The drug is a direct inhibitor of thrombin and, binding it, prevents the formation of thrombi. The drug is used:

• in the treatment and prevention of thrombosis of the limbs;
• in the prevention of strokes , systemic thromboembolism;
• to reduce the risk of complications in atrial fibrillation.

Xarelto (rivaroxaban)

Direct inhibitor of factor Xa (coagulation factor, which is a prothrombin activator). The drug inhibits the formation of new molecules of thrombin and does not affect those already present in the bloodstream. Used for prevention:

• thromboembolism after orthopedic operations on the lower limbs;
• strokes and systemic thromboembolism in patients with atrial fibrillation.

Which is better - Pradaksa, Xarelto or Warfarin?

A clear advantage of Pradax, like Xarelto, is that these drugs do not require INR control and, when taken, less risk of side effects. However, these drugs They are used only for non-valvular forms of heart disease. That is, if there are artificial valves or rheumatic damage to the heart valves, they are not prescribed, in contrast to Warfarin.

When choosing between Xarelto and Pradaksa, it is worth considering that Xarelto is taken only once a day, and Pradaksa may require several techniques. In addition, it is believed that Xarelto is not so traumatic affects the gastrointestinal tract.

Since all these drugs affect vital indicators, it is up to the doctor to determine exactly what warfarin is to be replaced and whether its analogs are acceptable.