Odeston is a choleretic preparation that is available in the form of tablets. O has a selective spasmolytic effect, without lowering blood pressure and peristalsis of the gastrointestinal tract. That is why the use of Odeston is indicated in cases of impaired activity of the bile duct and gall bladder.
Mechanism of action of Odeston
The active substance of this drug is gimecromone. Thanks to him, after using Odeston, the musculature of both the bile ducts and the gall bladder quickly relaxes. Because of this property it is used for dyskinesia of these organs by the hypertonic type, when they are constantly in a state of spasm, which does not allow the bile to move in a timely manner. As a result, it stagnates and gallstones form.
The use of Odeston is also indicated for dyskinesia and because it has an instant selective spasmolytic effect on the sphincter of Oddi. This is important, since bile from the gallbladder enters the intestine through the common bile duct, which before it merges with the duct, originating in the pancreas. A smooth muscle, surrounding part of these ducts, is called the sphincter of Oddi. Its relaxation allows the gallbladder to be emptied in a timely manner. This is also an excellent prevention of bile stasis. In addition, with spasms of the sphincter of Oddi, the pancreas suffers, because such a large amount of pancreatic juice can provoke the development of acute pancreatitis .
Indications for the application of Odeston
Indications for the use of the drug are:
- a severe inflammatory process, based in the biliary tract;
- cholelithiasis without complications;
- violation of the function of the sphincter of Oddi;
- liver diseases, which are accompanied by stagnation of bile ;
- a lowered secretion of bile accompanied by impaired appetite, constipation, nausea, or vomiting.
Also, this drug should be used to prepare patients for surgical intervention on both the gall bladder and bile ducts.
If there is evidence for the use of Ooston, you should strictly follow the dosage. Take it about half an hour before eating 1-2 tablets three times a day. The course of treatment Odeston should not exceed 3 weeks.
Contraindications to the application of Odeston
Contra-indications for the use of Odeston include:
- hypersensitivity to this drug;
- obstruction of the bile ducts;
- erosive and ulcerative processes in the digestive tract;
- various diseases of the liver or kidneys that affected the function of these organs;
- a strong decrease in blood clotting capacity.
Side Effects of Odeston
This drug does not affect the secretion of digestive juice or absorption processes in the intestine, but after using Odeston tablets, there may be various side effects from the gastrointestinal tract:
- diarrhea;
- bloating;
- painful sensations;
- erosive and ulcerative changes (only with prolonged treatment).
Some patients may experience clotting and headaches. In rare cases, symptoms worsen
It is strictly forbidden to take Odeston at the same time as an anesthetic drug Morphine, as it reduces its effect and causes a spasm of the sphincter of Oddi. It is also forbidden to use such tablets to those who are assigned to receive Cerucal. With this treatment, the effects of both drugs are weakened. With drugs that lower blood coagulation, Odeston can be taken, but it should be noted that it significantly enhances their effect.