Nonsteroidal anti-inflammatory drugs (NSAIDs) are a group of effective medicines that have the following antipyretic, anti-inflammatory and analgesic effect.
Thus, these drugs help to reduce pain, fever and inflammation. Their action is based on the inhibition of certain enzymes, through which the synthesis of substances that catalyze the inflammatory process occurs in the body. In contrast to glucocorticoids (hormonal agents), the effect of which is similar, non-steroid pain medications do not possess such a multitude of undesirable properties.
In addition, some NSAIDs have anti-aggregation effect (dilution, improvement of blood fluidity), as well as immunosuppressive effect (artificial suppression of immunity).
Indications for use of NSAIDs
In general, non-steroidal anti-inflammatory drugs are used in acute and chronic diseases, accompanied by inflammation and pain. Let's list a number of pathologies, in which the following preparations of the given group are recommended:
- osteoarthritis;
- rheumatoid arthritis;
- gout;
- headache, migraine ;
- fever;
- neurological diseases;
- dysmenorrhea;
- renal colic;
- metastases of bones;
- postoperative pain syndrome;
- inflammatory arthropathy.
List of non-steroidal anti-inflammatory drugs
The list of modern non-steroidal anti-inflammatory drugs is now quite wide. They are classified according to the chemical structure and nature of the activity. Also different forms of non-steroidal anti-inflammatory drugs are divided: tablets, capsules, ointments, gels, suppositories, injectable solutions, etc.
Consider the main types of NSAIDs:
- Salicylates:
- Aspirin;
- Diflunisal;
- lysine monoacetyl salicylate.
- Indomethacin;
- Sulindak;
- This is eelander.
- Diclofenac ;
- Aceclofenac.
- Ibuprofen;
- Ketoprofen;
- Tiaprofenic acid;
- Naproxen;
- Flurbiprofen;
- Fenbufen;
- Fenoprofen;
- Nabumethon.
- Lornoxicam;
- Tenoxicam;
- Piroxicam;
- Meloksikam.
- Rofecoxib;
- Nimesulide;
- Celecoxib.
From the given preparations on analgesic action, such drugs as Ketorolac, Ketoprofen, Diclofenac, Indomethacin are most effective. The best anti-inflammatory properties are Indomethacin, Flurbiprofen, Diclofenac and Piroxicam.
It is worth noting that non-steroidal anti-inflammatory drugs go on sale under various trade names. Therefore, when purchasing a medicine in a pharmacy, first of all, one should pay attention to the international name.
Nonsteroidal anti-inflammatory drugs of the new generation
Nonsteroidal anti-inflammatory drugs of the new generation operate more selectively and show the highest activity in comparison with their predecessors. In this case, virtually no side effects from the gastrointestinal tract.
Representatives of new drugs of the NSAID group are oxycam.
NSAIDs also have their contraindications:
- erosive and ulcerative lesions of the gastrointestinal tract;
- marked violations of the liver and kidneys;
- cytopenia;
- pregnancy;
- individual intolerance.